Volume 14, Issue 20

October 31, 2022pp 8140—8581

About the Cover

The cover features Figure 4 "Effects of SFRP4 knockdown on the skin of aging mice" from Takaya et al.

Research Perspectives

Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice

Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.204354pp 8140—8149

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Lamin A to Z in normal aging

Stanley R. Primmer, Chen-Yu Liao, Oona M.P. Kummert, Brian K. Kennedy

https://doi.org/10.18632/aging.204342pp 8150—8166

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Research Papers

Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging

Kento Takaya, Toru Asou, Kazuo Kishi

https://doi.org/10.18632/aging.204273pp 8167—8178

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Crosstalk between age accumulated DNA-damage and the SIRT1-AKT-GSK3ß axis in urine derived renal progenitor cells

Lars Erichsen, James Adjaye

https://doi.org/10.18632/aging.204300pp 8179—8204

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Age-associated changes in microglia activation and Sirtuin-1- chromatin binding patterns

Liana V. Basova, Nikki Bortell, Bruno Conti, Howard S. Fox, Richard Milner, Maria Cecilia Garibaldi Marcondes

https://doi.org/10.18632/aging.204329pp 8205—8220

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AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

Paul Dent, Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M. Reiman

https://doi.org/10.18632/aging.204337pp 8221—8242

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Network analysis for the identification of hub genes and related molecules as potential biomarkers associated with the differentiation of bone marrow-derived stem cells into hepatocytes

Ying-Hao Han, Xin-Mei He, Seung-Jae Lee, Ying-Ying Mao, Xuan-Chen Liu, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon

https://doi.org/10.18632/aging.204344pp 8243—8257

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Association between Epstein-Barr virus serological reactivation and psychological distress: a cross-sectional study of Japanese community-dwelling older adults

Hirotomo Yamanashi, Shogo Akabame, Jun Miyata, Yukiko Honda, Fumiaki Nonaka, Yuji Shimizu, Seiko Nakamichi, Shin-Ya Kawashiri, Mami Tamai, Kazuhiko Arima, Atsushi Kawakami, Kiyoshi Aoyagi, Takahiro Maeda

https://doi.org/10.18632/aging.204345pp 8258—8269

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Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan

Prameet Kaur, Agimaa Otgonbaatar, Anupriya Ramamoorthy, Ellora Hui Zhen Chua, Nathan Harmston, Jan Gruber, Nicholas S. Tolwinski

https://doi.org/10.18632/aging.204347pp 8270—8291

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α-Synuclein upregulates bim-mediated apoptosis by negatively regulating endogenous GCN5

Shofiul Azam, In-Su Kim, Dong-Kug Choi

https://doi.org/10.18632/aging.204353pp 8292—8301

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Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats

He Tai, Xiao-Zheng Cui, Jia He, Zhi-Ming Lan, Shun-Min Li, Ling-Bing Li, Si-Cheng Yao, Xiao-Lin Jiang, Xian-Sheng Meng, Jin-Song Kuang

https://doi.org/10.18632/aging.204304pp 8302—8320

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Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF

Xiao-Lin Jiang, He Tai, Jin-Song Kuang, Jing-Yi Zhang, Shi-Chao Cui, Yu-Xuan Lu, Shu-Bo Qi, Shi-Yu Zhang, Shun-Min Li, Jian-Ping Chen, Xian-Sheng Meng

https://doi.org/10.18632/aging.204320pp 8321—8345

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Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC

Xiaorong Liu, Zhaofeng Gao, Xiaoguang Wang, Yiyu Shen

https://doi.org/10.18632/aging.204339pp 8346—8356

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Identify miRNA-mRNA regulation pairs to explore potential pathogenesis of lung adenocarcinoma

Xingchen Fan, Xuan Zou, Cheng Liu, Shuang Peng, Shiyu Zhang, Xin Zhou, Jun Zhu, Wei Zhu

https://doi.org/10.18632/aging.204341pp 8357—8373

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Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder

Ning Bao, Jiping Liu, Zhe Peng, Rong Zhang, Rufei Ni, Runzuan Li, Jian Wu, Zhenhua Liu, Botao Pan

https://doi.org/10.18632/aging.204348pp 8374—8393

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Computational study on new natural compound inhibitors of Traf2 and Nck-interacting kinase (TNIK)

Lushun Ma, Rui Li, Zhiwei Yao, Bo Wang, Yong Liu, Chunxiang Liu, Heng Wang, Shuxian Chen, Daqing Sun

https://doi.org/10.18632/aging.204349pp 8394—8410

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ZNF320 is a hypomethylated prognostic biomarker involved in immune infiltration of hepatocellular carcinoma and associated with cell cycle

Jing Zhen, Yun Ke, Jingying Pan, Minqin Zhou, Hong Zeng, Gelin Song, Zichuan Yu, Bidong Fu, Yue Liu, Da Huang, Honghu Wu

https://doi.org/10.18632/aging.204350pp 8411—8436

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Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding

Mingzhou Gao, Hao Zhang, Ya Sun, Zhan Gao, Chunyan Sun, Fengqin Wei, Dongmei Gao

https://doi.org/10.18632/aging.204351pp 8437—8447

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Sex differences in major cardiovascular outcomes and fractures in patients with subclinical thyroid dysfunction: a systematic review and meta-analysis

Hongjuan Fang, Runsheng Zhao, Shuang Cui, Weiqing Wan

https://doi.org/10.18632/aging.204352pp 8448—8485

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The regulatory mechanism of HSP70 in endoplasmic reticulum stress in pepsin-treated laryngeal epithelium cells and laryngeal cancer cells

Wei Chen, Zhiyi Wang, Junfeng Ji, Tao Shi, Hong ye Jiao, You Cheng, Li Xu, Rui Wang

https://doi.org/10.18632/aging.204356pp 8486—8497

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Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer

Su-Chi Ku, Hsin-Liang Liu, Che-Yu Su, I-Jeng Yeh, Meng-Chi Yen, Gangga Anuraga, Hoang Dang Khoa Ta, Chung-Chieh Chiao, Do Thi Minh Xuan, Fidelia Berenice Prayugo, Wei-Jan Wang, Chih-Yang Wang

https://doi.org/10.18632/aging.204357pp 8498—8567

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