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Research Paper|Volume 16, Issue 1|pp 28—42

High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma

Yihang Ma1, Bing Chen2, Boyin Zhang1, Chao Zhang3, Qingsan Zhu1, Xu Wang1, Zhengang Liu1, Haochuan Liu1
  • 1Department of Spine Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China
  • 2Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China
  • 3Department of Operating Room, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China
Received: August 9, 2023Accepted: October 19, 2023Published: November 22, 2023
https://doi.org/10.18632/aging.205235

Copyright: © 2024 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Osteosarcoma is a malignant tumor, accounting for 20% of primary malignant bone tumors worldwide. However, the role of IBSP as a biomarker in osteosarcoma progression has not been studied yet.

Methods: 85 cases of IBSP expression and clinical characteristics were obtained from TARGET database. Through the Kaplan-Meier curve, subgroup analysis, and univariate and multivariate Cox analysis, we further assessed the independent predictive capacity of IBSP expression for overall survival (OS) and relapse-free survival (RFS).

Results: The mRNA expression of IBSP was higher in osteosarcoma than normal tissue (P < 0.0001). IBSP expression grouped by vital status showed statistical differences (P = 0.042). The race (P = 0.0183), vital status (P = 0.0034), and sample type (P = 0.0020) showed significant differences. IBSP expression exhibited satisfied diagnostic ability for osteosarcoma. The univariate and multivariate analysis confirmed that IBSP expression was an independent risk factor for OS (HR = 3.425, 95% CI: 1.604–7.313, P = 0.002) and RFS (HR = 3.377, 95% CI: 1.775–6.424, P < 0.001) in osteosarcoma patients. High IBSP expression was significantly associated with poor OS and RFS (P < 0.0001). The higher IBSP expression was observed in osteosarcoma (P < 0.001), confirmed by the IHC staining. The CCK-8 and colony formation assay showed that IBSP knockdown inhibits cell proliferation while overexpression promotes cell proliferation (P < 0.05).

Conclusion: High expression of IBSP was associated with poor OS and RFS. IBSP could serve as a potential biomarker for osteosarcoma, which could aid in early detection and disease monitoring.