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Research Paper|Volume 14, Issue 21|pp 8585—8594

Abnormal myocardial enzymes in the prediction of mortality and hypertension in COVID-19 patients: a retrospective study

Shuang Sha1, Min Liu2, Miaomiao Sun3, Long Xiao4, Qing Chang5,6, Ying Chen7, Jie Huang8
  • 1Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
  • 2Department of Hospital Infection Control, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China
  • 3Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
  • 4Yunmeng County People’s Hospital, Yunmeng 432500, China
  • 5Clinical Research Center, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai 201800, China
  • 6Shanghai General Practice Medical Education and Research Center, Shanghai 201800, China
  • 7Department of Education and Training Office, Huangshi Central Hospital, Huangshi 435000, China
  • 8Department of Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
* Equal contribution
Received: September 27, 2021Accepted: October 21, 2022Published: November 2, 2022
https://doi.org/10.18632/aging.204362

Copyright: © 2022 Sha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study aims to determine the differences in myocardial enzymes in COVID-19 patients with and without hypertension. A total of 130 patients with COVID-19 in Yunmeng County People's Hospital were analyzed. The clinical manifestations and laboratory indicators were collected and analyzed. We found that COVID-19 patients with hypertension had higher mortality rate, greater age, and higher rates of basic disease such as diabetes than patients without hypertension. The γ-glutamyl transpeptidase (GGT), blood urea nitrogen (BUN), albumin/globulin (A/G), Ca, Mg, lactate dehydrogenase (LDH), and α-hydroxybutyric-dehydrogenase (α-HBD) levels in COVID-19 patients with hypertension were higher than in COVID-19 patients without hypertension. We found that the predictive effect of the creatine kinase isoenzyme (CK-MB), LDH-L, and α-HBD levels in the COVID-19 patients without hypertension were higher than in COVID-19 patients with hypertension. We used the ROC curve model to predict whether patients would have hypertension, and we found that CK-MB, LDH-L and HBD parameters could distinguish the COVID-19 patients with hypertension and non-hypertension, and could predict the mortality of COVID-19 patients.