Research Paper|Volume 14, Issue 11|pp 4888—4896

Effects of Qidantang Granule on early stage of diabetic kidney disease in rats

Tengfei Wu¹, Xinyu Yang¹, Yilei Cong¹, Shisi Xia¹, Bowen Liu¹, Ran Zou¹, Juanhua Zeng¹, Hua Yang¹

¹Department of Endocrinology, Longhua Hospital, Shanghai University of TCM, Shanghai 200032, China

* Equal contribution

Received: February 21, 2022Accepted: June 1, 2022Published: June 13, 2022

https://doi.org/10.18632/aging.204121

Copyright: © 2022 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Diabetic kidney disease (DKD), is one of the most common vascular diseases caused by diabetes, eventually progressing into glomerular sclerosis. Qidantang Granule is a traditional Chinese medicine that is commonly used for DKD. However, there is still no experimental evidence for its effectiveness on DKD. 8-week-old Sprague Dawley male rats were fed on high-fat and high-sugar diet for 4 weeks, and then intraperitoneally injected with 35 mg/kg streptozotocin (STZ) to induce diabetes. Diabetic rats were randomly divided into three groups, and orally administrated with vehicle, 50 mg/kg or 200 mg/kg Qidantang Granule respectively, once daily for 9 weeks. Qidantang Granule effectively reduced food and water intake, body weight and fasting blood glucose, decreased inflammation and oxidative stress, ameliorated renal injury through suppressing PI3K signaling pathway in STZ-induced DKD rats. Our results provide experimental evidence to demonstrate the pharmacological mechanism of Qidantang Granule in the treatment of DKD.