Research Paper|Volume 14, Issue 10|pp 4211—4219

The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China

Xiao-Chun Song¹, Xue-Hui Zhou¹, Jing-Hui Cheng¹, Wen-Hao Zhang¹, Xiao Shen¹, Huan Xu¹, Shuai Nie¹, Ji-Lai Xiao¹, Fang Sun¹, Chang Shu¹, Jiu-Dong Chen¹, Yan Tang¹, Xiang Wang¹, Xin-Pei Sun², Jia-Kui Sun¹, Ping Feng¹, Qian-Kun Shi¹

¹Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
²Department of General Office, Productivity Center of Jiangsu Province, Nanjing 210042, Jiangsu Province, China

* Equal contribution

Received: November 25, 2021Accepted: May 7, 2022Published: May 18, 2022

https://doi.org/10.18632/aging.204085

Copyright: © 2022 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The coronavirus disease 2019 (COVID-19) is spreading around the world. The COVID-19 vaccines may improve concerns about the pandemic. However, the roles of inactivated vaccines in older patients (aged ≥60 years) with infection of Delta variant were less studied.

Methods: We classified the older patients with infection of Delta variant into three groups based on the vaccination status: no vaccination (group A, n = 113), one dose of vaccination (group B, n = 46), and two doses of vaccination (group C, n = 22). Two inactivated COVID-19 vaccines (BBIBP-CorV or CoronaVac) were evaluated in this study. The demographic data, laboratory parameters, and clinical severity were recorded.

Results: A total of 181 older patients with infection of Delta variant were enrolled. 111 (61.3%) patients had one or more co-morbidities. The days of "turn negative" and hospital stay in Group C were lower than those in the other groups (P < 0.05). The incidences of multiple organ dysfunction syndrome (MODS), septic shock, acute respiratory distress syndrome (ARDS), acute kidney injury, and cardiac injury in Group A were higher than those in the other groups (P < 0.05). The MV-free days and ICU-free days during 28 days in Group A were also lower than those in the other groups (P < 0.05). In patients with co-morbidities, vaccinated cases had lower incidences of MODS (P = 0.015), septic shock (P = 0.015), and ARDS (P = 0.008).

Conclusions: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.