Research Paper Volume 14, Issue 5 pp 2252—2267
Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer
- 1 Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan
- 2 School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
- 3 Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
- 4 Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan
- 5 National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
- 6 Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
- 7 Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
- 8 Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
- 9 Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Received: October 13, 2021 Accepted: March 1, 2022 Published: March 5, 2022
https://doi.org/10.18632/aging.203933How to Cite
Copyright: © 2022 Chu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The human ATP binding cassette (ABC) family of transporter proteins plays an important role in the maintenance of homeostasis in vivo. The aim of this study is to evaluate the potential diagnostic, prognostic, and therapeutic value of the ABCA10 gene in BRCA. We found that ABCA10 expression was downregulated in different subgroups of breast cancer and strongly correlated with pathological stage in BRCA patients. Low expression of ABCA10 was associated with BRCA patients showing shorter overall survival (OS). ABCA10 expression may be regulated by promoter methylation, copy number variation (CNV) and kinase, and is associated with immune infiltration. Our study also demonstrated the potential role of ABCA10 modifications in tumor microenvironment (TME) cellular infiltration. Nevertheless, the regulatory mechanism remains unknown and immunotherapy is marginal in BRCA. We demonstrate the expression of different ABCA10 modulators in breast cancer associated with genetic variants, deletions, tumor mutation burden (TMB) and TME. Mutations in ABCA10 are positively associated with different immune cells in six different immune databases and play an important role in immune cell infiltration in breast cancer. Overall, this study provides evidence that ABCA10 could become the potential targets for precision treatment and new biomarkers in the prognosis of breast cancer.