Research Paper|Volume 12, Issue 11|pp 11071—11084

LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK

Gong Zhang¹, Ximin Chen², Lei Ma², Rui Ding¹, Lihong Zhao¹, Feng Ma³, Xubin Deng²

¹Department of Radiotherapy, People's Hospital of Shanxi Province, Taiyuan, China
²Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China
³Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, China

Received: February 24, 2020Accepted: April 28, 2020Published: June 10, 2020

Copyright © 2020 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment.