COVID-19 Research Paper Volume 12, Issue 11 pp 10070—10086
Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages
- 1 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- 2 Cardiovascular Research Institute, Wuhan University, Wuhan, China
- 3 Hubei Key Laboratory of Cardiology, Wuhan, China
- 4 Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
- 5 Department of Medical Affairs, Renmin Hospital of Wuhan University, Wuhan, China
- 6 Medical Quality Management Office, Renmin Hospital of Wuhan University, Wuhan, China
- 7 Department of Emergency, Renmin Hospital of Wuhan University, Wuhan, China
- 8 Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China
Received: April 9, 2020 Accepted: April 30, 2020 Published: June 4, 2020
https://doi.org/10.18632/aging.103298How to Cite
Copyright © 2020 Zhao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Information about the clinical characteristics and mortality of patients with coronavirus disease 2019 at different ages is limited.
Results: The older group had more patients with dyspnea and fewer patients with fever and muscle pain. Older patients had more underlying diseases, secondary infection, myocardial injury, renal dysfunction, coagulation dysfunction, and immune dysfunction on admission. More older patients received immunoglobulin therapy and mechanical ventilation. The proportions of patients with multiple organ injuries, critically ill patients and death increased significantly with age. The older groups had higher cumulative death risk than the younger group. Hypertension, cerebrovascular disease, comorbidities, acute cardiac injury, shock and complications are independent predictors of death.
Conclusions: The symptoms of the elderly patients were more atypical, with more comorbidities, secondary infection, organ injuries, immune dysfunction and a higher risk of critical illness. Older age was an important risk factor for mortality.
Methods: 1000 patients diagnosed with coronavirus disease 2019 from January 1, 2020 to February 14, 2020 were enrolled. According to age, patients were divided into group 1 (<60 years old), group 2 (60-74 years old) and group 3 (≥75 years old). The clinical symptoms, first laboratory results, CT findings, organ injuries, disease severity and mortality were analyzed.
Abbreviations
COVID-19: coronavirus disease 2019; WHO: World Health Organization; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; SARS: severe acute respiratory syndrome; MERS: Middle East respiratory syndrome; CAD: coronary artery disease; CVD: cerebrovascular disease; hs-TnI: hypersensitive troponin I; CKMB: creatinine kinases MB isoenzyme; LDH: lactate dehydrogenase; CRP: C-reactive protein; hs-CRP: high-sensitivity C-reactive protein; PCT: procalcitonin; SAA: serum amyloid protein; IL: interleukin; ICU: intensive care unit; CRRT: continuous renal replacement therapy; ECMO: extracorporeal membrane oxygenation; ALSS: artificial liver support system; ALT: alanine aminotransferase; ALI: acute liver injury; AKI: acute kidney injury; Scr: serum creatinine; CT: computed tomography; IQR: interquartile ranges; HR: hazard ratio; CI: confidence interval.