Research Paper Volume 12, Issue 11 pp 10259—10274
Structural plasticity of the bilateral hippocampus in glioma patients
- 1 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
- 2 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 3 Beijing Institute for Brain Disorders Brain Tumor Center, Beijing, China
- 4 China National Clinical Research Center for Neurological Diseases, Beijing, China
- 5 State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Received: January 9, 2020 Accepted: April 17, 2020 Published: June 5, 2020
https://doi.org/10.18632/aging.103212How to Cite
Copyright © 2020 Yuan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
This study investigates the structural plasticity and neuronal reaction of the hippocampus in glioma patient pre-surgery. Ninety-nine glioma patients without bilateral hippocampus involvement (low-grade, n=52; high-grade, n=47) and 80 healthy controls with 3D T1 images and resting-fMRI were included. Hippocampal volume and dynamic amplitude of low-frequency fluctuation (dALFF) were analyzed among groups. Relationships between hippocampal volume and clinical characteristics were assessed. We observed remote hippocampal volume increases in low- and high-grade glioma and a greater response of the ipsilateral hippocampus than the contralesional hippocampus. The bilateral hippocampal dALFF was significantly increased in high-grade glioma. Tumor-associated epilepsy and the IDH-1 mutation did not affect hippocampal volume in glioma patients. No significant relationship between hippocampal volume and age was observed in high-grade glioma. The Kaplan-Meier curve and log-rank test revealed that large hippocampal volume was associated with shorter overall survival (OS) compared with small hippocampal volume (p=0.007). Multivariate Cox regression analysis revealed that large hippocampal volume was an independent predictor of unfavorable OS (HR=3.597, 95% CI: 1.160-11.153, p=0.027) in high-grade glioma. Our findings suggest that the hippocampus has a remarkable degree of plasticity in response to pathological stimulation of glioma and that the hippocampal reaction to glioma may be related to tumor malignancy.
Abbreviations
dALFF: Dynamic amplitude of low-frequency fluctuation; VBM: Voxel based morphometry; HGG: High-grade glioma; LGG: Low-grade glioma; GMV: gray matter volume; TAE: Tumor associated epilepsy.