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Review|Volume 11, Issue 17|pp 7307—7327

Metabolic remodeling induced by mitokines in heart failure

Jiahao Duan1, Zijun Chen1, Yeshun Wu1, Bin Zhu2, Ling Yang1, Chun Yang3
  • 1Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
  • 2Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
  • 3Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Received: July 17, 2019Accepted: August 22, 2019Published: September 9, 2019
https://doi.org/10.18632/aging.102247

Copyright © 2019 Duan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The prevalence rates of heart failure (HF) are greater than 10% in individuals aged >75 years, indicating an intrinsic link between aging and HF. It has been recognized that mitochondrial dysfunction contributes to the pathology of HF. Mitokines are a type of cytokines, peptides, or signaling pathways produced or activated by the nucleus or the mitochondria through cell non-autonomous responses during cellular stress. In addition to promoting the communication between the mitochondria and the nucleus, mitokines also exert a systemic regulatory effect by circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related HF risk factors and are associated with HF severity. Consequently, mitokines might represent a potential therapy target for HF.