Review Volume 11, Issue 17 pp 7307—7327
Metabolic remodeling induced by mitokines in heart failure
- 1 Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
- 2 Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
- 3 Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Received: July 17, 2019 Accepted: August 22, 2019 Published: September 9, 2019
https://doi.org/10.18632/aging.102247How to Cite
Copyright © 2019 Duan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The prevalence rates of heart failure (HF) are greater than 10% in individuals aged >75 years, indicating an intrinsic link between aging and HF. It has been recognized that mitochondrial dysfunction contributes to the pathology of HF. Mitokines are a type of cytokines, peptides, or signaling pathways produced or activated by the nucleus or the mitochondria through cell non-autonomous responses during cellular stress. In addition to promoting the communication between the mitochondria and the nucleus, mitokines also exert a systemic regulatory effect by circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related HF risk factors and are associated with HF severity. Consequently, mitokines might represent a potential therapy target for HF.