Research Paper Volume 11, Issue 15 pp 5786—5806
A defined human aging phenome
- 1 Center for Healthy Aging, Department of Cellular and Molecular Medicine University of Copenhagen, Copenhagen, Denmark
Received: April 13, 2019 Accepted: August 5, 2019 Published: August 12, 2019
https://doi.org/10.18632/aging.102166How to Cite
Copyright © 2019 Andreassen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aging is among the most complex phenotypes that occur in humans. Identifying the interplay between different age-associated features is undoubtedly critical to our understanding of aging and thus age-associated diseases. Nevertheless, what constitutes human aging is not well characterized. Towards this end, we mined millions of PubMed abstracts for age-associated terms, enabling us to generate a detailed description of the human aging phenotype. We discovered age-associated features in clusters that can be broadly associated with previously defined hallmarks of aging, consequently identifying areas where interventions could be pursued. Importantly, we validated the newly discovered features by manually verifying the prevalence of these features in combined cohorts describing 76 million individuals, allowing us to stratify features in aging that appear to be the most prominent. In conclusion, we propose a comprehensive landscape of human aging: the human aging phenome.