Research Paper Volume 10, Issue 12 pp 4166—4174
Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
- 1 Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan
- 2 Athletic Training and Health Department, National Taiwan Sport University, Taoyuan, Taiwan, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan
- 3 Medical Research Center for Exosome and Mitochondria Related Diseases, China Medical University and Hospital, Taichung, Taiwan
- 4 Department of Nursing, Meiho University, Pingtung, Taiwan
- 5 Department of Healthcare Administration, Asia University, Taichung, Taiwan
- 6 Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 7 Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan
- 8 Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China
- 9 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
- 10 Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
- 11 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
- 12 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
Received: August 30, 2018 Accepted: December 6, 2018 Published: December 23, 2018
https://doi.org/10.18632/aging.101714How to Cite
Abstract
Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and AMPKα1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that long-term exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.