Research Paper|Volume 10, Issue 4|pp 632—644

KCNQ1OT1 promotes melanoma growth and metastasis

Bingyu Guo¹, Qian Zhang¹, Hongyi Wang¹, Peng Chang¹, Kai Tao¹

¹Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, China

Received: March 16, 2018Accepted: April 10, 2018Published: April 17, 2018

Copyright: © 2018 Guo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma.