Research Paper Volume 8, Issue 10 pp 2414—2424
Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function
- 1 Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 2 Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 3 Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 4 Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 5 Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461
- 6 Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Received: July 23, 2016 Accepted: September 28, 2016 Published: October 14, 2016
https://doi.org/10.18632/aging.101063How to Cite
Abstract
Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test, grip-strength, and gait speed. Muscle mass was estimated using the skeletal muscle index. Serum IGF-I was measured with liquid chromatography mass spectrometry. In gender stratified age-adjusted logistic regression analysis, females with IGF-I levels in the first tertile had lower odds of being cognitively impaired compared to females with IGF-I levels within the upper two tertiles, OR (95% CI) 0.39 (0.19-0.82). The result remained significant after adjustment for multiple parameters. No significant association was identified in males between IGF-I and cognition. No relationship was found between IGF-I tertiles and muscle function and muscle mass in females or males. Lower circulating IGF-I is associated with better cognitive function in females with exceptional longevity, with no detriment to skeletal muscle mass and function.