Research Paper Volume 8, Issue 5 pp 1135—1148
Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
- 1 Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK
- 2 School of Medicine, MVLS, University of Glasgow, Glasgow, UK
- 3 Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK
- 4 Division of Renal Medicine M99, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Received: January 26, 2016 Accepted: April 16, 2016 Published: April 26, 2016
https://doi.org/10.18632/aging.100948How to Cite
Abstract
Background
We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.
Results
We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.
Conclusions
Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.