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Research Paper|Volume 8, Issue 5|pp 1135—1148

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Ruth McClelland1, Kelly Christensen1, Suhaib Mohammed1, Dagmara McGuinness1, Josephine Cooney2, Andisheh Bakshi3, Evangelia Demou3, Ewan MacDonald3, Muriel Caslake2, Peter Stenvinkel4, Paul G. G. Shiels1
  • 1Institute of Cancer Sciences, MVLS, University of Glasgow, Glasgow, UK
  • 2School of Medicine, MVLS, University of Glasgow, Glasgow, UK
  • 3Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK
  • 4Division of Renal Medicine M99, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Received: January 26, 2016Accepted: April 16, 2016Published: April 26, 2016
https://doi.org/10.18632/aging.100948

Copyright: © 2016 McClelland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background

We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.

Results

We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.

Conclusions

Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.