Research Perspective|Volume 3, Issue 5|pp 543—547

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Carles Cantó¹, Johan Auwerx

¹Ecole Polytechnique Fédérale de Lausanne; CH-1015 Lausanne, Switzerland

Received: May 5, 2011Accepted: May 6, 2011Published: May 7, 2011

Abstract

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.