Research Perspective Volume 3, Issue 4 pp 430—437
The physiological roles of Sirt1 in skeletal muscle
- 1 Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, One Baylor Plaza 825E, Houston TX 77030
Received: March 11, 2011 Accepted: March 27, 2011 Published: March 28, 2011
https://doi.org/10.18632/aging.100312How to Cite
Abstract
Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.