Research Perspective|Volume 3, Issue 4|pp 430—437

The physiological roles of Sirt1 in skeletal muscle

Patricia S. Pardo¹, Aladin M. Boriek

¹Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, One Baylor Plaza 825E, Houston TX 77030

Received: March 11, 2011Accepted: March 27, 2011Published: March 28, 2011

Copyright: © 2011 Pardo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.