Special Collection on Cancer Therapeutics

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice

Marina P. Antoch, Michelle Wrobel, Karen K. Kuropatwinski, Ilya Gitlin, Katerina I. Leonova, Ilia Toshkov, Anatoli S. Gleiberman, Alan D. Hutson, Olga B. Chernova, Andrei V. Gudkov,

https://doi.org/10.18632/aging.101206 pp 615—626

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Delivery of sFIT-1 engineered MSCs in combination with a continuous low-dose doxorubicin treatment prevents growth of liver cancer

Jian Niu, Yue Wang, Ji Wang, Liu Bin, Xin Hu,

https://doi.org/10.18632/aging.101146 pp 3520—3534

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RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma

Mingzhi Zhang, Zijun Y. Xu-Monette, Ling Li, Ganiraju C. Manyam, Carlo Visco, Alexandar Tzankov, Jing Wang, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Ben M. Parsons, Jane N. Winter, Miguel A. Piris, L. Jeffrey Medeiros, Lan V. Pham, Ken H. Young,

https://doi.org/10.18632/aging.101121 pp 3321—3340

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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Yingying Wang, Jianhui Chang, Xingui Liu, Xuan Zhang, Suping Zhang, Xin Zhang, Daohong Zhou, Guangrong Zheng,

https://doi.org/10.18632/aging.101100 pp 2915—2926

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PI3Kα inhibition reduces obesity in mice

Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Sonia Martinez, Joaquin Pastor, Pablo J. Fernandez-Marcos, Manuel Serrano,

https://doi.org/10.18632/aging.101075 pp 2747—2753

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Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

Alejandro Vazquez-Martin, Chris Van Van den Haute, Sílvia Cufí, Bruna Corominas Corominas-Faja, Elisabet Cuyàs, Eugeni Lopez-Bonet, Esther Rodriguez-Gallego, Salvador Fernández-Arroyo, Jorge Joven, Veerle Baekelandt, Javier A. A. Menendez,

https://doi.org/10.18632/aging.100976 pp 1330—1349

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Potential targeted therapeutic approaches in liposarcoma

Deepika Kanojia, Manoj Garg, H. Phillip Koeffler,

https://doi.org/10.18632/aging.100945 pp 569—570

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci, Alessia Garufi, Gabriella D'Orazi,

https://doi.org/10.18632/aging.100934 pp 603—619

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Fasting plus tyrosine kinase inhibitors in cancer

Irene Caffa, Valter D. Longo, Alessio Nencioni,

https://doi.org/10.18632/aging.100857 pp 1026—1027

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A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition

Clemens Stockklausner, Simon Raffel, Julia Klermund, Obul Reddy Bandapalli, Fabian Beier, Tim H. Brümmendorf, Friederike Bürger, Sven W. Sauer, Georg F. Hoffmann, Holger Lorenz, Laura Tagliaferri, Daniel Nowak, Wolf-Karsten Hofmann, Rebecca Buergermeister, Carolin Kerber, Tobias Rausch, Jan O. Korbel, Brian Luke, Andreas Trumpp, Andreas E. Kulozik,

https://doi.org/10.18632/aging.100835 pp 911—927

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The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells

Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P. Mikhaiel, Venkata Yenugonda, Olga C. Rodriguez, Sana D. Karam, Brian R. Rood, Maria Laura Avantaggiati, Chris Albanese,

https://doi.org/10.18632/aging.100831 pp 854—867

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Kinase overexpressing cancers responsive to drug withdrawal

Amit Dipak Amin, Soumya S. Rajan, Jonathan H. Schatz,

https://doi.org/10.18632/aging.100830 pp 752—753

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Sonic Hedgehog in SCLC

Mikko O. Laukkanen, J Silvio Gutkind, Maria Domenica Castellone,

https://doi.org/10.18632/aging.100817 pp 605—606

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Targeting of non-oncogene addiction

Ana Igea, Jalaj Gupta, Angel R. Nebreda,

https://doi.org/10.18632/aging.100796 pp 525—526

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Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo

Marta G. Novelle, Ashley Davis, Nathan L. Price, Ahmed Ali, Stefanie Fürer-Galvan, Yongqing Zhang, Kevin Becker, Michel Bernier, Rafael de Cabo,

https://doi.org/10.18632/aging.100732 pp 233—240

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Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma

Fabio Marongiu, Maria Paola Serra, Marcella Sini, Fabrizio Angius, Ezio Laconi,

https://doi.org/10.18632/aging.100631 pp 26—34

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Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production

Shubhankar Suman, Olga C. Rodriguez, Thomas A. Winters, Albert J. Fornace Jr, Chris Albanese, Kamal Datta,

https://doi.org/10.18632/aging.100587 pp 607—622

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

Elena A. Komarova, Marina P. Antoch, Liliya R. Novototskaya, Olga B. Chernova, Geraldine Paszkiewicz, Olga V. Leontieva, Mikhail V. Blagosklonny, Andrei V. Gudkov,

https://doi.org/10.18632/aging.100498 pp 709—714

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Reversing the aging stromal phenotype prevents carcinoma initiation

Davina A. Lewis, Jeffrey B. Travers, Christiane Machado, Ally-Khan Somani, Dan F Spandau,

https://doi.org/10.18632/aging.100318 pp 407—416

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Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis

He Ming, Qiu Chuang, Wang Jiashi, Li Bin, Wang Guangbin, Ji Xianglu,

https://doi.org/10.18632/aging.101710 pp 4141—4151

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Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203

Liang Wang, Zhewei Wei, Kaiming Wu, Weigang Dai, Changhua Zhang, Jianjun Peng, Yulong He,

https://doi.org/10.18632/aging.101628 pp 3662—3682

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A four-methylated mRNA signature-based risk score system predicts survival in patients with hepatocellular carcinoma

Yu Wang, Zhiping Ruan, Sizhe Yu, Tao Tian, Xuan Liang, Li Jing, Wenyuan Li, Xiao Wang, LCL Xiang, F.X. Claret, Kejun Nan, Hui Guo,

https://doi.org/10.18632/aging.101738 pp 160—173

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First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Béla Ózsvári, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.103336 pp 10162—10179

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Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway

Yizhou Yao, Xuchao Wang, Diyuan Zhou, Hao Li, Huan Qian, Jiawen Zhang, Linhua Jiang, Bin Wang, Qi Lin, Xinguo Zhu,

https://doi.org/10.18632/aging.103393 pp 13059—13075

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Coupled immune stratification and identification of therapeutic candidates in patients with lung adenocarcinoma

Weilei Hu, Guosheng Wang, Yundi Chen, Lonny B. Yarmus, Biao Liu, Yuan Wan,

https://doi.org/10.18632/aging.103775 pp 16514—16538

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Mimetics of extra virgin olive oil phenols with anti-cancer stem cell activity

Elisabet Cuyàs, Juan Gumuzio, Jesús Lozano-Sánchez, Antonio Segura-Carretero, Sara Verdura, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Alfons Nonell-Canals, Amadeu Llebaria, Silvia Cabello, Carme Serra, Melchor Sanchez-Martinez, Ángel G. Martin, Javier A. Menendez,

https://doi.org/10.18632/aging.202154 pp 21057—21075

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Targeting FTO for cancer therapy and more

Ying Qing, Rui Su, Jianjun Chen,

https://doi.org/10.18632/aging.203404 pp 19080—19082

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Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics

Rocio I.R. Macias, Maria J. Monte, Maria A. Serrano, Jesús M. González-Santiago, Isabel Martín-Arribas, André L. Simão, Rui E. Castro, Javier González-Gallego, José L. Mauriz, Jose J.G. Marin,

https://doi.org/10.18632/aging.203620 pp 23416—23434

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Identification of a novel immune signature for optimizing prognosis and treatment prediction in colorectal cancer

Yan Li, Yiyi Li, Zijin Xia, Dun Zhang, Xiaomei Chen, Xinyu Wang, Jing Liao, Wei Yi, Jun Chen,

https://doi.org/10.18632/aging.203771 pp 25518—25549

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TIMP-2 regulates 5-Fu resistance via the ERK/MAPK signaling pathway in colorectal cancer

Guolin Zhang, Xin Luo, Zian Wang, Jianbin Xu, Wei Zhang, Engeng Chen, Qing Meng, Di Wang, Xuefeng Huang, Wei Zhou, Zhangfa Song,

https://doi.org/10.18632/aging.203793 pp 297—315

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Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin α₆β₁ drives endocrine resistance in breast cancer cells

Ingrid Espinoza, Lin Yang, Travis Vander Steen, Luciano Vellon, Elisabet Cuyàs, Sara Verdura, Lester Lau, Javier A. Menendez, Ruth Lupu,

https://doi.org/10.18632/aging.203882 pp 1200—1213

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Mechanisms of action of triptolide against colorectal cancer: insights from proteomic and phosphoproteomic analyses

Xinqiang Song, Huanhuan He, Yu Zhang, Jinke Fan, Lei Wang,

https://doi.org/10.18632/aging.203992 pp 3084—3104

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Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer

Xiaofei Zhang, Tiebo Mao, Haiyan Xu, Shumin Li, Ming Yue, Jingyu Ma, Jiayu Yao, Yongchao Wang, Xiao Zhang, Weiyu Ge, Yanling Wang, Daiyuan Shentu, Liwei Wang,

https://doi.org/10.18632/aging.204031 pp 3597—3606

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microRNA-569 inhibits tumor metastasis in pancreatic cancer by directly targeting NUSAP1

Xiaohui Guo, Yatian Li, Xiaofang Che, Kezuo Hou, Xiujuan Qu, Ce Li,

https://doi.org/10.18632/aging.204035 pp 3652—3665

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Hallmarks of cancer and hallmarks of aging

Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.204082 pp 4176—4187

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Special Collection on Cancer Therapeutics

Marina P. Antoch, Michelle Wrobel, Karen K. Kuropatwinski, Ilya Gitlin, Katerina I. Leonova, Ilia Toshkov, Anatoli S. Gleiberman, Alan D. Hutson, Olga B. Chernova, Andrei V. Gudkov,

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Jian Niu, Yue Wang, Ji Wang, Liu Bin, Xin Hu,

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Yingying Wang, Jianhui Chang, Xingui Liu, Xuan Zhang, Suping Zhang, Xin Zhang, Daohong Zhou, Guangrong Zheng,

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Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Sonia Martinez, Joaquin Pastor, Pablo J. Fernandez-Marcos, Manuel Serrano,

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Alejandro Vazquez-Martin, Chris Van Van den Haute, Sílvia Cufí, Bruna Corominas Corominas-Faja, Elisabet Cuyàs, Eugeni Lopez-Bonet, Esther Rodriguez-Gallego, Salvador Fernández-Arroyo, Jorge Joven, Veerle Baekelandt, Javier A. A. Menendez,

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Deepika Kanojia, Manoj Garg, H. Phillip Koeffler,

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Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci, Alessia Garufi, Gabriella D'Orazi,

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Irene Caffa, Valter D. Longo, Alessio Nencioni,

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Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P. Mikhaiel, Venkata Yenugonda, Olga C. Rodriguez, Sana D. Karam, Brian R. Rood, Maria Laura Avantaggiati, Chris Albanese,

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Amit Dipak Amin, Soumya S. Rajan, Jonathan H. Schatz,

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Mikko O. Laukkanen, J Silvio Gutkind, Maria Domenica Castellone,

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Ana Igea, Jalaj Gupta, Angel R. Nebreda,

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Marta G. Novelle, Ashley Davis, Nathan L. Price, Ahmed Ali, Stefanie Fürer-Galvan, Yongqing Zhang, Kevin Becker, Michel Bernier, Rafael de Cabo,

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Fabio Marongiu, Maria Paola Serra, Marcella Sini, Fabrizio Angius, Ezio Laconi,

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Shubhankar Suman, Olga C. Rodriguez, Thomas A. Winters, Albert J. Fornace Jr, Chris Albanese, Kamal Datta,

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Elena A. Komarova, Marina P. Antoch, Liliya R. Novototskaya, Olga B. Chernova, Geraldine Paszkiewicz, Olga V. Leontieva, Mikhail V. Blagosklonny, Andrei V. Gudkov,

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Davina A. Lewis, Jeffrey B. Travers, Christiane Machado, Ally-Khan Somani, Dan F Spandau,

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He Ming, Qiu Chuang, Wang Jiashi, Li Bin, Wang Guangbin, Ji Xianglu,

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Liang Wang, Zhewei Wei, Kaiming Wu, Weigang Dai, Changhua Zhang, Jianjun Peng, Yulong He,