Aging-US: Helicobacter pylori infection and risk for developing dementia
10-25-2021Aging-US published "Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies" which reported that infection with multiple pathogens may play a key role in the pathogenesis of dementia.
Whether Helicobacter pylori infection is associated causally with dementia is controversial. The authors conduct a meta-analysis of case-control and cohort studies on the association between H. pylori infection and the risk for all-cause and Alzheimer’s disease dementia. There was no association between H.
Dr. Hao Li from The China Academy of Chinese Medical Sciences said, "Dementia is a serious social and medical problem that affects the health of people older than 65 years worldwide."
The most common types of dementia were Alzheimer’s disease and vascular dementia, accounting for 60%-70% and 30%, respectively. Currently, there are more than 50 million people with dementia worldwide, and this number will increase to 152 million by 2050. In addition, infections, diabetes, hypertension, and stroke can also contribute to the occurrence of dementia.
Currently, there are more than 50 million people with dementia worldwide, and this number will increase to 152 million by 2050
Emerging data have demonstrated that infection with several important pathogens may be a hazard factor for cognitive impairment, dementia, and AD in particular. Chronic H. pylori infection is a direct inducement of chronic gastritis, peptic ulcers, and gastric cancer. Interestingly, H. pylori has also been identified as a risk factor for non-gastrointestinal diseases, such as neurodegenerative diseases, including all-cause and AD dementia.
Figure 4. Forest plot presents the association between Helicobacter pylori infection and the risk of Alzheimer’s disease in case-control study.
Previous evidence suggests H. pylori infection as a driver of cognitive decline. The potential link between H. pylori infection and dementia have been investigated by several population-based case-control and cohort studies, but the results were inconsistent.
The Li Research Team concluded in their Aging-US Research Output, "this systematic review and meta-analysis suggest that H. pylori infection may be associated with an increased risk of all-cause dementia, but not AD dementia. Future research on the pathogenic mechanism between the two diseases may lead to the development of novel therapies. The clinical implications lie in maintaining vigilance against dementia in elderly patients infected with H. pylori, and early detection and timely medical treatment for H. pylori patients through a multidisciplinary approach."
Full Text - https://www.aging-us.com/article/203571/text
Correspondence to: Hao Li email: 20190931822@bucm.edu.cn
Keywords: helicobacter pylori, dementia, Alzheimer’s disease, systematic review and meta-analysis
About Aging-US:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
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