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The Aging Mouse Prostate: Kinetics of Lymphocyte Infiltration

05-23-2023

“This dataset presents the most comprehensive profiling of the aging adult mouse prostate immune profile to date.”

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BUFFALO, NY- May 23, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate.”

Aging is a significant risk factor for disease in several tissues, including the prostate. Defining the kinetics of age-related changes in these tissues is critical for identifying regulators of aging and evaluating interventions to slow the aging process and reduce disease risk. An altered immune microenvironment is characteristic of prostatic aging in mice, but whether features of aging in the prostate emerge predominantly in old age or earlier in adulthood has not previously been established.

In this study, researchers Jonathan J. Fox, Takao Hashimoto, Héctor I. Navarro, Alejandro J. Garcia, Benjamin L. Shou, and Andrew S. Goldstein from the University of California Los Angeles tracked the abundance of 29 immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling and time-course analysis. 

“In this study, we characterized how the inflammatory microenvironment of the adult mouse prostate changes during aging using highly-multiplexed single-cell mass cytometry.”

Early in adulthood, myeloid cells comprise the vast majority of immune cells in the 3-month-old mouse prostate. Between 6 and 12 months of age, there is a profound shift towards a T and B lymphocyte-dominant mouse prostate immune microenvironment. Comparing the prostate to other urogenital tissues, the researchers found similar features of age-related inflammation in the mouse bladder but not the kidney. 

“In summary, our study offers new insight into the kinetics of prostatic inflammaging and the window when interventions to slow down age-related changes may be most effective.”

Read the full study: DOI: https://doi.org/10.18632/aging.204708 

Corresponding Author: Andrew S. Goldstein

Corresponding Email: AGoldstein@mednet.ucla.edu 

Keywords: prostate, immune microenvironment, mass cytometry, inflammation, lymphocyte

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About Aging-US:

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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