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Volume 3, Issue 11

November 2011pp 1039—1123

Editorial Comments

Intermittent supplementation with rapamycin as a dietary restriction mimetic

Valter D Longo, Luigi Fontana

https://doi.org/10.18632/aging.100401pp 1039—1040

Chronological lifespan in stationary culture: from yeast to human cells

Zoya N. Demidenko

https://doi.org/10.18632/aging.100406pp 1041—1042

Rapamycin: Killing two birds with one stone

Amit Khanna, Pankaj Kapahi

https://doi.org/10.18632/aging.100405pp 1043—1044

Hypotheses

SkQ1 treatment and food restriction — two ways to retard an aging program of organisms

Vladimir P. Skulachev

https://doi.org/10.18632/aging.100410pp 1045—1050

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Hormesis does not make sense except in the light of TOR-driven aging

Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.100411pp 1051—1062

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Research Perspective

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

Javier A. Menendez, Sílvia Cufí, Cristina Oliveras-Ferraros, Begoña Martin-Castillo, Jorge Joven, Luciano Vellon, Alejandro Vazquez-Martin

https://doi.org/10.18632/aging.100407pp 1063—1077

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Research Papers

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

Olga V. Leontieva, Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.100402pp 1078—1091

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Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus

Yuko Maejima, Daisuke Kohno, Yusaku Iwasaki, Toshihiko Yada

https://doi.org/10.18632/aging.100400pp 1092—1097

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Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Lan Xiang, Yukiko Nakamura, Young-Mi Lim, Yasutoyo Yamasaki, Yumi Kurokawa-Nose, Wakako Maruyama, Toshihiko Osawa, Akira Matsuura, Noboru Motoyama, Leo Tsuda

https://doi.org/10.18632/aging.100396pp 1098—1109

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Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents

Vladimir N. Anisimov, Maxim V. Egorov, Marina S. Krasilshchikova, Konstantin G. Lyamzaev, Vasily N. Manskikh, Mikhail P. Moshkin, Evgeny A. Novikov, Irina G. Popovich, Konstantin A. Rogovin, Irina G. Shabalina, Olga N. Shekarova, Maxim V. Skulachev, Tatiana V. Titova, Vladimir A. Vygodin, Mikhail Yu. Vyssokikh, Maria N. Yurova, Mark A. Zabezhinsky, Vladimir P. Skulachev

https://doi.org/10.18632/aging.100404pp 1110—1119

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Letter to the Editor

Aging as a particular case of phenoptosis, the programmed death of an organism (A response to Kirkwood and Melov “On the programmed/non-programmed nature of ageing within the life history”)

Vladimir P. Skulachev

https://doi.org/10.18632/aging.100403pp 1120—1123