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Volume 1, Issue 1

January 2009pp 1—145

Editorial

Aging: past, present and future

Mikhail V. Blagosklonny, Judith Campisi, David A. Sinclair

https://doi.org/10.18632/aging.100009pp 1—5

Previews

Longevity regulation in flies: A role for p53

Lawrence A. Donehower

https://doi.org/10.18632/aging.100010pp 6—8

Breathing lessons: Tor tackles the mitochondria

Toren Finkel

https://doi.org/10.18632/aging.100013pp 9—11

Sirtuins at the Breaking Point: SIRT6 in DNA Repair

David B. Lombard

https://doi.org/10.18632/aging.100014pp 12—16

Reviews

Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging

German Perdomo, H. Henry Dong

https://doi.org/10.18632/aging.100004pp 17—27

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Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

Phillip R. Musich, Yue Zou

https://doi.org/10.18632/aging.100012pp 28—37

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Research Papers

dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster

Johannes H. Bauer, Siti Nur Sarah Morris, Chengyi Chang, Thomas Flatt, Jason G. Wood, Stephen L. Helfand

https://doi.org/10.18632/aging.100001pp 38—48

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Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival

Kaisa Selesniemi, Ho-Joon Lee, Teruko Niikura, Jonathan L. Tilly

https://doi.org/10.18632/aging.100002pp 49—57

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Dual regulation of TERT activity through transcription and splicing by ΔNP63α

Esther Vorovich, Edward A. Ratovitski

https://doi.org/10.18632/aging.100003pp 58—67

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Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE)

Sharda P. Singh, Maciej Niemczyk, Ludwika Zimniak, Piotr Zimniak

https://doi.org/10.18632/aging.100005pp 68—80

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The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration

Elissa S. Epel, Sharon Stein Merkin, Richard Cawthon, Elizabeth H. Blackburn, Nancy E. Adler, Mark J. Pletcher, Teresa E. Seeman

https://doi.org/10.18632/aging.100007pp 81—88

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Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53

Katherine Heminger, Michael Markey, Meldrick Mpagi, Steven J. Berberich

https://doi.org/10.18632/aging.100008pp 89—108

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SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

Ronald A. McCord, Eriko Michishita, Tao Hong, Elisabeth Berber, Lisa D. Boxer, Rika Kusumoto, Shenheng Guan, Xiaobing Shi, Or Gozani, Alma L. Burlingame, Vilhelm A. Bohr, Katrin F. Chua

https://doi.org/10.18632/aging.100011pp 109—121

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Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas

Sebastian Begemann, Francesco Galimi, Jan Karlseder

https://doi.org/10.18632/aging.100015pp 122—130

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Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

Yong Pan, Gerald S. Shadel

https://doi.org/10.18632/aging.100016pp 131—145

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