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Volume 15, Issue 3

February 14, 2023pp 597—881

About the Cover

The cover features Figure 4 "Platelet depletion impairs amyloid beta phagocytosis by microglia" from de Sousa et al.

Editorials

Harnessing the vasculo-protective potential of microglia

Sebok K. Halder, Arjun Sapkota, Richard Milner

https://doi.org/10.18632/aging.204509pp 597—598

Untangling IGF-I signaling in the aging brain

Jonathan Zegarra-Valdivia, Angel Nuñez, Ignacio Torres Aleman

https://doi.org/10.18632/aging.204507pp 599—600

Research Papers

Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

Pedro S. Marra, Takehiko Yamanashi, Kaitlyn J. Crutchley, Nadia E. Wahba, Zoe-Ella M. Anderson, Manisha Modukuri, Gloria Chang, Tammy Tran, Masaaki Iwata, Hyunkeun Ryan Cho, Gen Shinozaki

https://doi.org/10.18632/aging.204498pp 601—616

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Epigenetic age and lung cancer risk in the CLUE II prospective cohort study

Dominique S. Michaud, Mei Chung, Naisi Zhao, Devin C. Koestler, Jiayun Lu, Elizabeth A. Platz, Karl T. Kelsey

https://doi.org/10.18632/aging.204501pp 617—629

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Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice

Diana M. Bessa de Sousa, Ariane Benedetti, Barbara Altendorfer, Heike Mrowetz, Michael S. Unger, Katharina Schallmoser, Ludwig Aigner, Kathrin Maria Kniewallner

https://doi.org/10.18632/aging.204502pp 630—649

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The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

Trisha A. Staab, Grace McIntyre, Lu Wang, Joycelyn Radeny, Lisa Bettcher, Melissa Guillen, Margaret P. Peck, Azia P. Kalil, Samantha P. Bromley, Daniel Raftery, Jason P. Chan

https://doi.org/10.18632/aging.204515pp 650—674

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Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos-induced hepatotoxicity in mice

Hongyan Pei, Silu Liu, Jianning Zeng, Jinze Liu, Hong Wu, Weijia Chen, Zhongmei He, Rui Du

https://doi.org/10.18632/aging.204298pp 675—688

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The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker of clinical cancer

Xiaowei Chen, Luhong Xie, Kun Qiao, Xiaoyu Zhu, Ji Ren, Yujie Tan

https://doi.org/10.18632/aging.204459pp 689—704

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miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

Housheng Yang, Zhiwen Wang, Shuang Hu, Lu Chen, Wei Li, Zhongyi Yang

https://doi.org/10.18632/aging.204474pp 705—717

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Interleukin 6 promotes BMP9-induced osteoblastic differentiation through Stat3/mTORC1 in mouse embryonic fibroblasts

Shi-Yu Wang, Jin-Hai Jiang, Si-Yuan Liu, Jie Zhang, Xiang Gao, Hang Liu, Kai-Xin Ke, Yue Jiang, Lu Liu, Bai-Cheng He

https://doi.org/10.18632/aging.204504pp 718—733

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MiR-181a-5p promotes osteogenesis by targeting BMP3

Ze Long, Pengcheng Dou, Weiliang Cai, Minzhi Mao, Ren Wu

https://doi.org/10.18632/aging.204505pp 734—747

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Intrinsic capacity differs from functional ability in predicting 10-year mortality and biological features in healthy aging: results from the I-Lan longitudinal aging study

Wei-Ju Lee, Li-Ning Peng, Ming-Hsien Lin, Ching-Hui Loh, Fei-Yuan Hsiao, Liang-Kung Chen

https://doi.org/10.18632/aging.204508pp 748—764

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Senolytic effect of high intensity interval exercise on human skeletal muscle

Wei-Horng Jean, Yu-Wen Hsieh, Li-Fan Lai, Luthfia Dewi, Yu-Chieh Liao, Mengxin Ye, Szu-Hsien Yu, Chung-Lan Kao, Chih-Yang Huang, Chia-Hua Kuo

https://doi.org/10.18632/aging.204511pp 765—776

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Comparison of the mutation patterns between tumor tissue and cell-free DNA in stage IV gastric cancer

Ching-Yun Kung, Wen-Liang Fang, Yi-Ping Hung, Kuo-Hung Huang, Ming-Huang Chen, Yee Chao, Shih-Chieh Lin, Anna Fen-Yau Li, Su-Shun Lo, Chew-Wun Wu

https://doi.org/10.18632/aging.204512pp 777—790

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Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

Hongliang Yang, Yan Zhang, Zhenwu Du, Tengfei Wu, Chun Yang

https://doi.org/10.18632/aging.204513pp 791—809

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Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis

Xiaojuan Li, Tianqi Wang, Mi Li, Xing Bao, Tian Ma, Caihong Yang, Hua Wu, Hao Li

https://doi.org/10.18632/aging.204517pp 810—829

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The context-dependent role of transforming growth factor-β/miR-378a-3p/connective tissue growth factor in vascular calcification: a translational study

You-Tien Tsai, Hsiang-Yuan Yeh, Chia-Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang

https://doi.org/10.18632/aging.204518pp 830—845

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Thyroid cancer risk prediction model using m6A RNA methylation regulators: integrated bioinformatics analysis and histological validation

Wei Zhou, Junchao Lin, Jinqiang Liu, Rui Zhang, Aqiang Fan, Qibin Xie, Liu Hong, Daiming Fan

https://doi.org/10.18632/aging.204525pp 846—865

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Differential expression profile of urinary exosomal microRNAs in patients with mesangial proliferative glomerulonephritis

Rong Dai, Lei Zhang, Hua Jin, Dong Wang, Meng Cheng, Yunhui Xu, Haiyin Zhang, Yiping Wang

https://doi.org/10.18632/aging.204527pp 866—880

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Retraction

Retraction: LncRNA AK045171 protects the heart from cardiac hypertrophy by regulating the SP1/MG53 signalling pathway

Li Xu, Hongjiang Wang, Feng Jiang, Hao Sun, Dapeng Zhang

https://doi.org/10.18632/aging.204530pp 881