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Research Paper|Volume 15, Issue 3|pp 705—717

miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

Housheng Yang1, Zhiwen Wang2, Shuang Hu3, Lu Chen4, Wei Li3, Zhongyi Yang3
  • 1School of Medicine, Hunan Normal University, Changsha 414006, Hunan, P.R. China
  • 2Key Laboratory of Chronic Noncommunicable Diseases, Yueyang Vocational Technical College, Yueyang 414006, Hunan, P.R. China
  • 3Yueyang Engineering Technology Research Center of Breast Disease Diagnosis and Treatment, Yueyang People’s Hospital, Yueyang Hospital Affiliated to Hunan Normal University, Yueyang 414006, Hunan, P.R. China
  • 4College of Health, Dongguan Polytechnic, Dongguan 523808, Guangdong, P.R. China
Received: September 20, 2022Accepted: December 27, 2022Published: January 10, 2023
https://doi.org/10.18632/aging.204474

Copyright: © 2023 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Breast cancer is an important cause of crisis for women’s life and health. Voltage-dependent anion channel 1 (VDAC1) is mainly localized in the outer mitochondrial membrane of all eukaryotes, and it plays a crucial role in the cell as the main interface between mitochondria and cellular metabolism. Through bioinformatics, we found that VDAC1 is abnormally highly expressed in breast cancer, and the prognosis of breast cancer patients with high VDAC1 expression is poor. Through in vivo and in vitro experiments, we found that VDAC1 can promote the proliferation, migration and invasion of breast cancer cells. Further research we found that VDAC1 can activate the wnt signaling pathway. Through analysis, we found that miR-874-3p can regulate the expression of VDAC1, and the expression of miR-874-3p is decreased in breast cancer, resulting in the increase of VDAC1 expression. Our findings will provide new targets and ideas for the prevention and treatment of breast cancer.