Research Paper Volume 16, Issue 4 pp 3955—3972
Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation
Figure 6. A proposed signaling pathway involved in triptolide against oxidative stress (OS) in ARPE-19 cells. The schematic diagram shows that TP induces Nrf2-mediated cytoprotective protein via activation of the PI3K/Akt signaling pathway, which protects against OS of ARPE-19 cells. Green arrows indicate stimulation, and red bars indicate inhibition.