Research Paper Volume 16, Issue 4 pp 3583—3595

Figure 3. Gene Ontology (G.O.) functional enrichment of differentially expressed genes (DEGs) in osteogenic differentiation of MSCs under the influence of rutin. These genes were enriched in various biological processes (B.P.), cellular components (CC), and molecular function (M.F.) terms. (A) The main enrichment results of DEGs. The ordinate is indicated on a −log10 (p-value) scale. (B) Chordplot shows the G.O. enrichment results for key regulatory genes. The left semicircle represents the enriched key genes (the color of the squares refers to the relative amount of change logFC of the genes), and the right semicircle refers to the GO term enriched by the key genes in different colors and is connected by ribbons in the color representing the GO term. (C) Heatmap of G.O. enrichment results, where the vertical axis indicates G.O. terms. The horizontal axis is the enriched genes, and the square pigmentation indicates the number of GO terms enriched for a particular gene.