Research Paper Volume 15, Issue 22 pp 12817—12851

Figure 5. CBX2 regulated CEP55 and CTNNB1 directly. (A) Summary of genomic distribution of CBX2 peaks. (B) Enriched GO terms in genes associated with gene promoter CBX2 peaks. (C) DNA motifs enriched within genes associated with gene promoter CBX2 peaks determined by HOMER motif analysis. (D, E) Tracks of CBX2 peaks on CEP55 (D) loci and CTNNB1 (E) loci and the corresponding expression between CBX2-statified tumors. Statistical significance was calculated using the two-sided Wilcoxon test. (F, G) mRNAsi distribution between CBX2-stratified (F) and CEP55-stratified (G) tumors. Statistical significance was calculated using the two-sided Wilcoxon test. (H) Kaplan-Meier plots of mRNAsi. The high and low group was classified with the median of risk score. P-value was computed with log-rank test.