Research Paper Volume 15, Issue 22 pp 12817—12851

Figure 4. CBX2 and CEP55 affected the cell cycle. (A) Summary of differential expressed genes identified using DESeq2 in CBX2-stratified and CEP55-stratified tumors. The genes in Up indicated the higher expression in CBX2^high or CEP55^high tumors whereas conversely for those in Down. (B, C) Enriched KEGG in 1887 CBX2-related up-regulated genes (B) and 2866 CEP55-related up-regulated genes (C) in stratified tumors. (D, E) GSEA analysis of CBX2-related (D) and CEP55-related (E) KEGG pathway. (F) GSEA analysis of CBX2-related and CEP55-related cancer hallmarks. (G) The Spearman’s correlation between pathway activity score and CBX2/CEP55 expression. (H) GSEA analysis of CBX2 knockdown -related KEGG pathways. (I) RNA and ATAC tracks of cell cycle-related genes in shCBX2 and WT group.