Research Paper Volume 15, Issue 22 pp 12817—12851

Figure 3. Genomic and epigenomic alternations enhanced CBX2 and CEP55 expressions. (A) From left to right, the figures were the Spearman’s correlation of CNV and the corresponding expression, the impact of CNV on patients’ survival time, and the percent of CBX2 and CEP55 CNV type detailly and broadly. KM P indicated the P-value computed with log-rank test. (B) Methylation level of CBX2 and CEP55 in HCC and adjacent tissues. P-value was performed using Wilcox rank sum test. (C) From left to right, the figures were the effects of methylation sites on CBX2 and CEP55 on patients’ survival, the mean methylation level of CBX2 and CEP55 in HCC and adjacent tissues, and the Spearman’s correlation between methylation level of methylation sites and expression level. The P-value reflecting differential methylation sites was derived from the Wilcox rank sum test. KM P indicated the P-value computed with log-rank test and the median of methylation level or expression level was utilized to classify the high and low group. (D) Chromatin accessibility signals on CBX2 and CEP55 in normal livers and HCC. (E) H3K4me3 signals on CBX2 and CEP55 in normal livers and HCC. HR, hazard ratio. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; OS, Overall Survival; DSS, Disease Specific Survival; DFI, Disease Free Interval; PFI, Progression Free Interval.