Research Paper Volume 15, Issue 20 pp 11313—11330
Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications
Figure 2. (A) The three figure parts show the different degrees of methylation of NF-κB-related genes in several human cancers, the relationship between methylation and mRNA expression level, and the correlation with patient prognosis. The colored circles indicate the value, and the size indicates the relationship with the p-value. (B) The relationship of NF-κB-related genes to 20 classical cellular pathways, “A” indicates activation and “I” indicates inhibition. (C) The relationship between NF-κB-related genes obtained in the GDSC database and drug sensitivity of individual targeted drugs, with blue indicating a positive correlation and orange indicating a negative correlation. (D) Immunofluorescence results from the HPA website showed the expression of IKBKB and IKBKG in the cytoplasm of u2os cells and the staining of the nucleus by DAPI.