Research Paper Volume 15, Issue 9 pp 3538—3548
m6A-mediated upregulation of lncRNA-AC026356.1 promotes cancer stem cell maintenance in lung adenocarcinoma via activating Wnt signaling pathway
Figure 3. m6A-mediated upregulation of AC026356.1 in lung adenocarcinoma. (A) The RNA m6A methylation site distribution of AC026356.1. (B) Correlation with AC026356.1 expression and METTL14/IGF2BP2 in lung adenocarcinoma. (C) The m6A methylation level of AC026356.1 after depletion of IGF2BP2 in NSCLC cell lines was examined by qRT-PCR assay. (D) The expression of AC026356.1 after depletion of IGF2BP2 in NSCLC cell lines was examined by qRT-PCR assay. (E) IGF2BP2 knockdown in A549 cells significantly downregulated AC026356.1 RNA abundance. (F) IGF2BP2 level in lung cancer by TCGA. (G) Prognosis of IGF2BP2 in lung cancer examined by TCGA and GEO dataset. (H, I) Expressing and prognosis of METTL14 in lung cancer by TCGA. ***p < 0.001.