Research Paper Volume 15, Issue 1 pp 119—133
Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer
Figure 3. Signaling transduction processes associated with the predictive signature. (A) Top ten gene ontology terms associated with circadian clock were shown, including mitotic nuclear division, wound healing, chromosome segregation. (B) Top ten KEGG signaling pathways associated with circadian clock were shown, including focal adhesion, ECM-receptor interaction, cell cycle, p53 signaling pathway, and apoptosis. (C) Crosstalk communication between these physiological and pathological processes showed these pathways are mutually related. (D) Multiple common genes were observed in these biological processes and signaling pathways. (E) There existed multiple shared genes in top 10 biological processes, implying a crosstalk between these biological functions. (F) There existed multiple shared genes in top 10 KEGG signaling pathways, suggesting an interaction between these pathways.