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Research Paper|Volume 16, Issue 22|pp 13662—13675

Gender-specification lifestyle factors associated with mild cognitive impairment among young-old adults in Taiwan

Su-Wen Chuang1,2, Ching-Wen Chen2, Meng-Chang Lee2, Yu-Hsuan Chen2, Wen Su3, Cheng-Jung Chen4,5, Wei-Teing Chen6,7, Po-Jen Hsiao8,9, Chih-Chien Chiu10,11, Sui-Lung Su1,2
  • 1Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
  • 2School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
  • 3Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan, ROC
  • 4Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
  • 5Taichung Veterans General Hospital Chiayi Branch, Chiayi City, Taiwan, ROC
  • 6Division of Thoracic Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, ROC
  • 7Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, ROC, Taiwan, ROC
  • 8Division of Nephrology, Department of Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, ROC
  • 9Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
  • 10Division of Infectious Disease, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, ROC
  • 11Division of Infectious Disease, Department of Internal Medicine, Tri-Service General Hospital, National, Defense Medical Center, Taipei, Taiwan, ROC
Received: April 4, 2024Accepted: November 15, 2024Published: December 10, 2024
https://doi.org/10.18632/aging.206172

Copyright: © 2024 Chuang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The prevalence of mild cognitive impairment (MCI) exhibits a positive correlation with age, particularly evident in the old-old female population. Lifestyle factors have been identified as crucial risk determinants for MCI. However, there is a scarcity of research focusing on lifestyle factors among young-old population.

Objective: This study aimed to explore the lifestyle factors associated with MCI in young-old male and female.

Methods: This study employed a cross-sectional design and utilized demographic and lifestyle data obtained from participants enrolled in the Taiwan Biobank (TWB) between 2008 and 2021, with 32,897 individuals aged 60 to 70 years old. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), with a total score ranging from 0 to 30 points. The cut-off of MCI scores was ≤18, ≤21, and ≤25 according to the education level, respectively. Logistic regression analysis was employed to assess the association between lifestyles and cognitive function.

Results: 3,878 individuals (11.78%) suffered from MCI. Upon gender stratification, high exercise metabolic equivalents in male (OR = 0.8, 95% CI: 0.70 - 0.92) and moderate exercise in female serve as protective factors for MCI (OR = 0.78, 95% CI: 0.70 - 0.87). Additionally, diversified dietary preferences among female (OR = 0.80, 95% CI: 0.66 - 0.97) also emerge as protective factors for cognitive function.

Conclusions: It is worth noting that male is advised to target a higher exercise metabolic equivalent, while female can attain cognitive benefits with moderate exercise and diversified dietary.