Research Paper Volume 16, Issue 17 pp 12293—12311
Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis
- 1 Department of Psychiatry, Fourth Hospital of Wuhu City, Wuhu, Anhui, China
- 2 Department of Psychiatry, Shenyang Mental Health Center, Shenyang, Liaoning, China
- 3 Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Received: February 19, 2024 Accepted: July 2, 2024 Published: August 28, 2024
https://doi.org/10.18632/aging.206087How to Cite
Copyright: © 2024 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
HTR1A C-1019G polymorphism (rs6295) and serotonin transporter promoter polymorphism (5-HTTLPR) have been linked with panic disorder (PD) in different ethnic backgrounds. Both these polymorphisms are in the promoter regions. However, results are inconsistent and contrasting evidence makes reliable conclusions even more challenging. A meta-analysis was conducted to test whether C-1019G polymorphism and 5-HTTLPR were involved in the etiology of PD. Articles researching the link between C-1019G, 5-HTTLPR polymorphisms, and PD were retrieved by database searching and systematically selected on the basis of selected inclusion parameters. 21 studies were included that examined the relationship of rs6295,5-HTTLPR polymorphisms with PD risk susceptibility (rs62957 polymorphism – 7 articles, and 5-HTTLPR polymorphism - 14 articles). A significant association was seen between the rs6295 polymorphism and PD pathogenesis, especially in Caucasian PD patients. No significant genetic linkage was found between the 5-HTTLPR polymorphism and PD. C-1019G polymorphism was involved in the etiology of PD in Caucasian patients. The 5-HTTLPR polymorphism was not a susceptibility factor of PD.
Abbreviations
5-HTTLPR: serotonin transporter promoter polymorphism; PD: panic disorder; SSRIs: selective serotonin-reuptake inhibitors; 5-HTT: serotonin transporter; 5-HTR1A: 5-HT1A receptor; PET: positron emission tomography; SNP: single nucleotide polymorphism; 5-HTT: serotoninergic transporter gene; HWE: Hardy-Weinberg equilibrium.