Copyright: © 2024 Grolaux et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The focus on maintaining health and vitality (e.g., good healthspan) in later life has become increasingly important as the world’s population is getting older. In the last decade, advances in aging research have identified biomarkers like DNA methylation (DNAm) and gene expression, offering insights into both chronological and biological aging. This understanding opens up possibilities for interventions that can slow down molecular aspects of the aging process. Exploring the impact of exercise on these biomarkers in human skeletal muscle (a critical tissue for metabolism, thermogenesis and movement) reveals its potential to foster healthier aging.