Editorial Volume 16, Issue 14 pp 11122—11124
Targeted cancer therapy: the initial high concentration may slow down the selection for resistance
- 1 Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
Received: July 5, 2024 Published: July 28, 2024
https://doi.org/10.18632/aging.206046How to Cite
Copyright: © 2024 Blagosklonny et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Unfortunately, any targeted therapy is, always, started with low levels of the drug in the organism, selecting for drug resistance. One should propose that initial drug levels must be maximized, and durations may be minimized, ideally, as portions of preemptive combination of targeted drugs.