Editorial|Volume 16, Issue 14|pp 11122—11124

Targeted cancer therapy: the initial high concentration may slow down the selection for resistance

Mikhail V. Blagosklonny¹

¹Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA

Received: July 5, 2024Published: July 28, 2024

https://doi.org/10.18632/aging.206046

Copyright: © 2024 Blagosklonny et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Unfortunately, any targeted therapy is, always, started with low levels of the drug in the organism, selecting for drug resistance. One should propose that initial drug levels must be maximized, and durations may be minimized, ideally, as portions of preemptive combination of targeted drugs.