Research Paper Volume 16, Issue 1 pp 714—745
LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior
- 1 Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang, China
- 2 Second College of Clinical Medicine, Nanchang University, Nanchang, China
- 3 Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China
Received: August 20, 2023 Accepted: November 21, 2023 Published: January 11, 2024
https://doi.org/10.18632/aging.205414How to Cite
Copyright: © 2024 Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies and its incidence and mortality continue apace. Lysosome-associated membrane protein 3 (LAMP3) is the third member of the LAMP family and its overexpression has been described to be involved in the progression of breast, ovarian and cervical cancers, but there has been an absence of research focusing on its role in UCEC.
Methods: WGCNA, TIMER, LinkedOmics, GSEA, Cytoscape, Kaplan-Meier plotter, GDC, GeneMANIA, cBioPortal, PDB, RNAinter, miRNet were applied in this research.
Results: Our study uncovers that LAMP3 possesses higher expression levels in UCEC compared to normal tissues, and this differential expression profile is tightly aligned with clinical and pathological features, and patients demonstrating high LAMP3 expression tend to have a shorter survival expectancy. The high expression of LAMP3 is modulated by the designated ceRNA network. LAMP3 is engaged in UCEC progression by functioning in a variety of biological roles of relevance to immunity. Furthermore, we predicted several prospering drugs based on drug sensitivity. Finally, we also constructed possible docking patterns of LAMP3 with ABCA3, RAB9A, and SGTB.
Conclusions: LAMP3 is a formidable biomarker for UCEC and could be a prospective candidate for the diagnosis, treatment and prognostic assessment of UCEC.
Abbreviations
UCEC: Uterine corpus endometrial carcinoma; LAMP3: Lysosome-associated membrane protein 3; TCGA: The Cancer Genome Atlas; GTEx: Genotype-Tissue Expression Project; WGCNA: Weighted gene co-expression network analysis; GO: Gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; GSEA: Gene set enrichment analysis; TIICs: Tumor infiltrating immune cells; ICB: Immune checkpoint blockade; ROC: Receiver operating characteristic curve; AUC: Area under curve; CTD: Comparative Toxicogenomics Database; PPI: Protein-protein interaction; m6A: N6-methyladenosine.