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Research Paper|Volume 14, Issue 19|pp 7866—7876

Comprehensive analysis of DTYMK for estimating the immune microenvironment, diagnosis, prognosis effect in patients with lung adenocarcinoma

Xi Chen1, Yixiao Yuan2, Fan Zhou3, Xiaobin Huang1, Jun Pu1, Xiaoqun Niu4, Xiulin Jiang5, Xiaoyan Ding6
  • 1Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
  • 2Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • 3Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
  • 4Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
  • 5College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China
  • 6Department of Oncology, The People’s Hospital of Lishui, Lishui 323000, Zhejiang, China
* Equal contribution
Received: May 13, 2022Accepted: September 17, 2022Published: September 27, 2022
https://doi.org/10.18632/aging.204308

Copyright: © 2022 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The expression of deoxythymidylate kinase (DTYMK) is up-regulated in liver cancer. However, the underlying biological function and potential mechanisms of DTYMK driving the progression of lung adenocarcinoma remains unclear. In this study, we investigated the role of DTYMK in lung adenocarcinoma and found that the expression of DTYMK in LUAD tissues was significantly higher than that of DTYMK expression in adjacent normal tissues. Kaplan-Meier survival analysis showed that patients with higher DTYMK expression correlated with adverse prognosis. ROC curve analysis showed that the AUC value of DTYMK was 0.914. Correlation analysis showed that DTYMK expression was associated with immune infiltration in LUAD. Finally, we determine that DTYMK regulated cell proliferation, cell migration, and cell cycle of lung adenocarcinoma in vitro. In conclusion, our data demonstrated that DTYMK was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for lung adenocarcinoma.