Research Paper Volume 14, Issue 10 pp 4556—4571
The impact of ALDH7A1 variants in oral cancer development and prognosis
- 1 Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
- 2 School of Medicine, Chung Shan Medical University, Taichung, Taiwan
- 3 Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan
- 4 Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan
- 5 Oral Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan
- 6 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
- 7 Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
- 8 Division of Hematology and Oncology, Department of Medicine, Changhua Christian Hospital, Changhua, Taiwan
- 9 School of Medicine, China Medical University, Taichung, Taiwan
- 10 Chinese Medicine Research Center, China Medical University, Taichung, Taiwan
- 11 Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan
- 12 Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan
- 13 Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
Received: November 4, 2021 Accepted: May 19, 2022 Published: May 25, 2022
https://doi.org/10.18632/aging.204099How to Cite
Copyright: © 2022 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The gene encoding aldehyde dehydrogenase 7 family member A1 (ALDH7A1) has been associated with the development and prognosis in multiple cancers; however, the role of ALDH7A1 polymorphisms in oral cancer remains unknown. For this purpose, the influences of ALDH7A1 rs13182402 and rs12659017 on oral cancer development and prognosis were analyzed. Our resulted showed that ALDH7A1 rs13182402 genotype had less pathologic nodal metastasis among betel quid chewer. ALDH7A1 rs13182402 also corresponded to higher expressions in upper aerodigestive mucosa, whole blood, the musculoskeletal system and oral cancer tissues than did the ALDH7A1 wild type. Furthermore, ALDH7A1 overexpression in oral cancer cells increased in vitro migration, whereas its silencing reduced cell migration. Conversely, ALDH7A1 expression in tumor tissues and in patients with advanced disease was lower than that in normal tissues and in patients with early-stage disease. When the patients were classified into ALDH7A1-high and -low-expression groups, the high-ALDH7A1 group had superior outcomes in progression-free survival than the low-ALDH7A1 group (5-year survival of 58.7% vs. 48.0%, P = 0.048) did. In conclusion, patients with high ALDH7A1 expression might, however, have more favorable prognoses than those with low ALDH7A1 expression have.