Research Paper|Volume 14, Issue 10|pp 4471—4485

NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma

Yiyue Xu^1,^2,^3,^4,^5,⁶, Bing Zou⁶, Bingjie Fan⁶, Butuo Li⁶, Jinming Yu⁶, Linlin Wang⁶, Jin Zhang^1,^2,^3,^4,⁵

¹3rd Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment and Research Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China
²Key Laboratory of Breast Cancer Prevention and Therapy of Ministry of Education, Tianjin, P.R. China
³Key Laboratory of Cancer Prevention and Therapy, Tianjin, P.R. China
⁴Tianjin’s Clinical Research Center for Cancer, Tianjin, P.R. China
⁵Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, P.R. China
⁶Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P.R. China

Received: February 6, 2022Accepted: May 7, 2022Published: May 18, 2022

https://doi.org/10.18632/aging.204087

Copyright: © 2022 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The development of novel treatments for breast invasive carcinoma (BC) has been stagnant. P2RX1, a member of the purinergic receptor family, has been found to have a prognostic impact in several tumors. Therefore, we analyzed the expression pattern of P2RX1 in pan-cancers including BC and its impact on survival and found that the expression level of P2RX1 was lower in BC compared with para-cancerous tissues, and higher P2RX1 expression indicated better prognoses. But real-time quantitative reverse transcription PCR (RT-qPCR) and Western blot detected that the P2RX1 expression in normal mammary epithelial cells was lower than that in tumor cells. Then we comprehensively analyzed the regulatory mechanism and protein-protein interaction network, and found that P2RX1 was significantly positively linked with immune cell infiltration and immune checkpoints.