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Research Paper|Volume 14, Issue 10|pp 4402—4424

Intra-tumoral angiogenesis correlates with immune features and prognosis in glioma

Qing Zhang1,2, Yao-Xing Guo1,2, Wan-Lin Zhang3, Hai-Yan Lian4, Natasha Iranzad5, Endi Wang5, Ying-Chun Li1, Hai-Chao Tong1, Le-Yao Li1, Ling-Yun Dong1, Lian-He Yang1,2, Shuang Ma1,2
  • 1Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China
  • 2Department of Neurology, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning, China
  • 3Department of Pathology, Hebei Petro China Central Hospital, Langfang, Hebei, China
  • 4Department of Ophthalmology, Jili Hospital of Liuyang (Liuyang Eye Hospital), Changsha, Hunan, China
  • 5Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
* Equal contribution
Received: April 2, 2021Accepted: April 22, 2022Published: May 17, 2022
https://doi.org/10.18632/aging.204079

Copyright: © 2022 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Gliomas are the most common malignant tumor in the brain. As with other tumors, the progression of glioma depends on intra-tumoral angiogenesis. However, the effect of angiogenesis on gliomas is still not fully understood. In this study, we developed an angiogenesis pathway score using Gene Set Variation Analysis (GSAV) in R to assess the status of intra-glioma angiogenesis in The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA mRNAseq_325, CGGA mRNA-array), and GSE16011 datasets. We found that the angiogenesis pathway score not only accurately predicted the prognosis of glioma patients, but also accurately distinguished the malignant phenotype and immune characteristics of gliomas. In addition, as an independent prognostic factor, the score could predict glioma sensitivity to radiotherapy and chemotherapy. In summary, we used the angiogenesis pathway score to reveal the relationship between glioma angiogenesis and the malignant phenotype, immune characteristics, and prognosis of glioma.