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Research Paper|Volume 13, Issue 24|pp 25846—25858

The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study

Yi-Hsuan Hsiao1,2,3, Pei-Ni Chen4,5, Min-Chien Hsin4,5, Po-Hui Wang4,6, Jing-Yang Huang4,5, Shun-Fa Yang4,5
  • 1Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
  • 2Women’s Health Research Laboratory, Changhua Christian Hospital, Changhua, Taiwan
  • 3School of Medicine, Chung Shan Medical University, Taichung, Taiwan
  • 4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  • 5Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
  • 6Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
Received: August 24, 2021Accepted: September 28, 2021Published: December 16, 2021
https://doi.org/10.18632/aging.203773

Copyright: © 2021 Hsiao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of the study was to determine the risk of distant metastases in patients with gynecologic cancers after surgery, including cervical, uterine and ovarian cancers. This is a retrospective study evaluating gynecologic cancer from 2009 to 2014 using population-based administrative datasets from the Health and Welfare Data Science Center (HWDC) and from The National Health Informatics Project (NHIP). A total of 1,464 gynecologic cancer patients, including 321 cervical cancer patients, 724 uterine cancer patients and 419 ovarian cancer patients, were analyzed retrospectively from 2009 to 2014. Among the cervical cancer patients, 173 (53.89%) received surgery only and 148 (46.11%) received surgery with radiotherapy /chemotherapy. Among the uterus cancer patients, 425(58.70%) received surgery only and 299 (41.3%) received surgery with radiotherapy /chemotherapy. Among the ovarian cancer patients, 81 (19.33%) received surgery only and 338 (80.67%) received surgery with radiotherapy/chemotherapy. Among patients with brain, liver or lung metastasis, cervical cancer patients have more cumulative metastasis-free survival than those ovarian cancer (p=0.0041). In analyzing liver metastasis based on primary cancer sites, cervical cancer patients and uterine cancer cases have more cumulative metastasis- free survival than those ovarian cancer (p<0.0001). In conclusion, ovarian cancer patients have higher risk of liver metastasis than cervical or uterine cancer. There were significantly different of pathological stage for cumulative metastasis-free survival among gynecologic cancer patients with brain or liver or lung metastasis. Pathological T stage remains the main predictive for distant metastasis of gynecologic cancer.