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Research Paper|Volume 13, Issue 17|pp 21421—21434

Low lean mass is associated with lower urinary tract symptoms in US men from the 2005–2006 national health and nutrition examination survey dataset

Zheng Qin1,2,3, Junjie Zhao4, Jiameng Li1,2,3, Qinbo Yang1,2,3, Jiwen Geng1,2,3, Ruoxi Liao1,2,3, Baihai Su1,2,3
  • 1Department of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China
  • 2Med+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu 610041, China
  • 3Med-X Center for Materials, Sichuan University, Chengdu 610041, China
  • 4West China School of Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Received: April 27, 2021Accepted: August 14, 2021Published: September 2, 2021
https://doi.org/10.18632/aging.203480

Copyright: © 2021 Qin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We investigated the relationship between low lean mass (LLM) and lower urinary tract symptoms (LUTS) using the 2005–2006 National Health and Nutrition Examination Survey (NHANES) dataset. We enrolled 959 men with an average age of 52.08 ± 7.91 years and performed weighted multiple regression analysis to determine the independent relationship between exposure variables (LLM, alternate LLM) and outcomes variables (urinary hesitancy, incomplete emptying, urinary frequency, nocturia, daytime LUTS, clinical LUTS) after adjusting for confounding factors. The prevalence of urinary hesitancy (OR = 7.76, P < 0.0001), incomplete emptying (OR = 2.49, P = 0.0070), urinary frequency (OR = 3.28, P < 0.0001), daytime LUTS (OR = 3.88, P < 0.0001) and clinical LUTS (OR = 8.11, P < 0.0001) was significantly higher among men with LLM compared to men without LLM. Moreover, alternate LLM (ALLM) was positively associated with urinary hesitancy (OR = 17.97, P < 0.0001), incomplete emptying (OR = 4.68, P = 0.0003), daytime LUTS (OR = 2.47, P = 0.0136) and clinical LUTS (OR = 12.18, P < 0.0001). These findings demonstrate that both LLM and ALLM were associated with a higher risk of LUTS in men aged ≥ 40 years, which suggested that early management and treatment of lean mass loss may improve or alleviate LUTS.