Review Volume 13, Issue 9 pp 13349—13358
Emerging roles of nucleotide metabolism in cancer development: progress and prospect
- 1 Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Fujian, Xiamen 361000, China
- 2 Department of Gastrointestinal Surgery, Zhongshan Hospital, Xiamen University, Fujian, Xiamen 361000, China
- 3 National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Guangxi Medical University, Guangxi, Nanning 53000, China
- 4 Medical College of Guangxi University, Guangxi, Nanning 530000, China
- 5 General Surgery Center, Bazhong Central Hospital, Sichuan, Bazhong 636000, China
Received: August 12, 2020 Accepted: March 29, 2021 Published: May 5, 2021
https://doi.org/10.18632/aging.202962How to Cite
Abstract
Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies have shown that abnormal nucleotide metabolism not only accelerates the development of tumors but also inhibits the normal immune response in the tumor microenvironment. Although few relevant experiments and reports are available, study of the interaction between nucleotide metabolism and cancer development is rapidly developing. The intervention, alteration or regulation of molecular mechanisms related to abnormal nucleotide metabolism in tumor cells has become a new idea and strategy for the treatment of tumors and prevention of recurrence and metastasis. Determining how nucleotide metabolism regulates the occurrence and progression of tumors still needs long-term and extensive research and exploration.