Review|Volume 13, Issue 9|pp 13349—13358

Emerging roles of nucleotide metabolism in cancer development: progress and prospect

Jingsong Ma^1,², Mengya Zhong^1,², Yubo Xiong^1,², Zhi Gao³, Zhengxin Wu⁴, Yu Liu⁵, Xuehui Hong^1,²

¹Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Fujian, Xiamen 361000, China
²Department of Gastrointestinal Surgery, Zhongshan Hospital, Xiamen University, Fujian, Xiamen 361000, China
³National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Guangxi Medical University, Guangxi, Nanning 53000, China
⁴Medical College of Guangxi University, Guangxi, Nanning 530000, China
⁵General Surgery Center, Bazhong Central Hospital, Sichuan, Bazhong 636000, China

Received: August 12, 2020Accepted: March 29, 2021Published: May 5, 2021

https://doi.org/10.18632/aging.202962

Copyright: © 2021 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies have shown that abnormal nucleotide metabolism not only accelerates the development of tumors but also inhibits the normal immune response in the tumor microenvironment. Although few relevant experiments and reports are available, study of the interaction between nucleotide metabolism and cancer development is rapidly developing. The intervention, alteration or regulation of molecular mechanisms related to abnormal nucleotide metabolism in tumor cells has become a new idea and strategy for the treatment of tumors and prevention of recurrence and metastasis. Determining how nucleotide metabolism regulates the occurrence and progression of tumors still needs long-term and extensive research and exploration.