Aging
Navigate
Submit an Article
Research Paper|Volume 13, Issue 8|pp 12058—12066

Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity

Kejin Huang1, Dan Liu2, Changlei Su3
  • 1Department of Gynecology, Harbin Medical University Tumor Hospital, Harbin 150001, China
  • 2The Seventh Department of Internal Medicine, Harbin Medical University Tumor Hospital, Harbin 150001, China
  • 3Department of General Surgery, The Second Hospital of Harbin Medical University, Harbin 150001, China
Received: December 2, 2020Accepted: March 4, 2021Published: April 25, 2021
https://doi.org/10.18632/aging.202911

Copyright: © 2021 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The critical importance of circular RNAs (circRNAs) in human cancers, including ovarian cancer, has been discovered in the recent years. However, the roles of circ_0007841 in ovarian cancer remain unknown. In the current study, it was found that circ_0007841 expression was upregulated in ovarian cancer tissues and cell lines. Upregulation of circ_0007841 in patients with ovarian cancer predicts poor prognosis. Loss-of-function experiments discovered that circ_0007841 knockdown suppressed the proliferation, migration and invasion of ovarian cancer cells in vitro and in vivo. In terms of mechanism, circ_0007841 worked as a competing endogenous RNA (ceRNA) for miR-151-3p to facilitate MEX3C expression. Restoration of MEX3C level recovered the proliferation, migration and invasion of ovarian cancer cells. In conclusion, this study demonstrated that circ_0007841/miR-151-3p/MEX3C axis exerted important oncogenic functions in ovarian cancer.