Research Paper Volume 13, Issue 5 pp 6375—6405
Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites
- 1 Gustave Roussy Comprehensive Cancer Institute, Villejuif, France
- 2 Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France
- 3 Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France
- 4 EverImmune, Villejuif, France
- 5 Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria
- 6 BioTechMed-Graz, Graz, Austria
- 7 Field of Excellence BioHealth, University of Graz, Graz, Austria
- 8 Inserm U1015, Villejuif, France
- 9 Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France
- 10 Faculty of Medicine, Université Paris Saclay, Le Kremlin-Bicêtre, France
- 11 Pôle De Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
- 12 Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China
- 13 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden
Received: January 21, 2021 Accepted: February 19, 2021 Published: March 2, 2021
https://doi.org/10.18632/aging.202739How to Cite
Copyright: © 2021 Grajeda-Iglesias et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The presence of Akkermansia muciniphila (Akk) in the human gut is associated with good health, leanness and fitness. Mouse experimentation has demonstrated positive effects for Akk, which counteracts aging, mediates antiobesity and antidiabetic effects, dampens inflammation and improves anticancer immunosurveillance. Clinical trials have confirmed antidiabetic effects for Akk. Here, we investigated the time-dependent effects of oral administration of Akk (which was live or pasteurized) and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma. Metabolomics was performed by a combination of chromatographic and mass spectrometric methods, yielding a total of 1.637.227 measurements. Akk had major effects on metabolism, causing an increase in spermidine and other polyamines in the gut and in the liver. Pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation. All these metabolites have previously been associated with human health, providing a biochemical basis for the beneficial effects of Akk.