Research Paper Volume 13, Issue 7 pp 9330—9347
Effects of multi-domain lifestyle interventions on sarcopenia measures and blood biomarkers: secondary analysis of a randomized controlled trial of community-dwelling pre-frail and frail older adults
- 1 Department of Medical Psychology and Ethics, School of Basic Medical Sciences, Shandong University, Jinan 250012, China
- 2 Performance and Technology Assessment Department, Ministry of Health, Singapore
- 3 Geriatric Medicine and Palliative Medicine Department, Ng Teng Fong General Hospital, Singapore
- 4 Biology of Ageing Laboratory, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore
- 5 Gerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- 6 Medical Services Department, St Luke’s Hospital, Singapore
- 7 Rehabilitation Services Division, St Luke’s Hospital, Singapore
- 8 Psychological Medicine Department, Khoo Teck Puat Hospital, Singapore
- 9 Nutrition and Dietetics Department, Khoo Teck Puat Hospital, Singapore
- 10 Geriatric Medicine Department, Khoo Teck Puat Hospital, Singapore
- 11 Geriatrics Division, Department of Medicine, Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec, Canada
Received: November 3, 2020 Accepted: February 9, 2021 Published: March 19, 2021
https://doi.org/10.18632/aging.202705How to Cite
Copyright: © 2021 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Few studies have comprehensively described changes in blood biomarkers of the physiological responses underlying sarcopenia reduction associated with lifestyle interventions. In this study, we performed secondary analyses of data in a randomized controlled trial of multi-domain lifestyle interventions (6-month duration physical exercise, nutritional enrichment, cognitive training, combination and standard care control) among 246 community-dwelling pre-frail and frail elderly, aged ≥65 years, with and without sarcopenia. Appendicular lean mass (ALM), lower limb strength, gait speed, and blood levels of markers of muscle metabolism, inflammation, anti-oxidation, anabolic hormone regulation, insulin signaling, tissue oxygenation were measured at baseline, 3-month and 6-month post-intervention. Multi-domain interventions were associated with significant (p < 0.001) reduction of sarcopenia at 3-month and 6-month post-intervention, improved gait speed, enhanced lower limb strength, and were equally evident among sarcopenic participants who were slower at baseline than non-sarcopenic participants. Active intervention was associated with significantly reduced inflammation levels. Sarcopenia status and reduction were associated with blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation. Physical, nutritional and cognitive intervention was associated with measures of sarcopenia reduction, together with changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia.