Research Paper Volume 12, Issue 22 pp 23296—23305
Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure
- 1 Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China
- 2 Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China
- 3 Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC 27708, USA
- 4 Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing 100871, China
- 5 Department of Ultrasound, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China
- 6 Central Laboratory, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China
Received: May 21, 2020 Accepted: September 9, 2020 Published: November 18, 2020
https://doi.org/10.18632/aging.104113How to Cite
Copyright: © 2020 Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Although abdominal obesity plays a fundamental role in the onset of immune and inflammatory reactions leading to cardiac abnormalities and premature mortality, the potential association between periumbilical fat and longevity mediated by the antibody-complement system and/or cardiac structure and function remains unclear. To address this issue, we collected biochemical and morphological data from 419 centenarians and 491 non-centenarian oldest-old individuals from the China Hainan Centenarian Cohort Study. Centenarians had lower waist circumference (WC), periumbilical fat thickness (PFT), serum complement C3 level, right atrium end-systolic diameter (RAESD), left atrium end-systolic diameter (LAESD), and left ventricular end-diastolic diameter (LVEDD) than non-centenarians (P<0.05 for all comparisons). WC, PFT, complement C3 levels, RAESD, LAESD, and LVEDD were inversely associated with centenarians (P<0.05 for all variables). Complement C3 level, LAESD, and LVEDD were positively associated with PFT and WC (P<0.05 for all variables). RAESD was positively associated with WC and complement C3 level (P<0.05 for both variables). Centenarians had less periumbilical fat, a weaker complement system, and smaller cardiac structure than non-centenarians. Importantly, periumbilical fat was inversely associated with longevity mediated by complement C3 and cardiac structure. This study suggests that successful aging can be promoted by increased efforts to prevent abdominal obesity.
Abbreviations
AOD: aorta diameter; CHCCS: China Hainan Centenarian Cohort Study; FBG: fasting blood glucose; LAESD: left atrium end systolic diameter; LVEDD: left ventricular end diastolic diameter; IVST: interventricular septum thickness; PAD: pulmonary artery diameter; PFT: periumbilical fat thickness; RAESD: right atrium end systolic diameter; WC: waist circumference.