Research Paper|Volume 12, Issue 21|pp 22046—22058

miR-205 inhibits the development of hypertrophic scars by targeting THBS1

Dongwen Jiang^1,², Bingyu Guo¹, Feng Lin¹, Shixiu Lin¹, Kai Tao¹

¹Reconstructive and Plastic Surgery, General Hospital of Northern Theater Command, Shenyang, P.R.China
²Graduate School, Jinzhou Medical University, Jinzhou 121001, P.R.China

* Equal contribution

Received: May 19, 2020Accepted: July 30, 2020Published: November 13, 2020

Copyright: © 2020 Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Increasing evidence shows that miRNAs are involved in the growth and development of hypertrophic scars. However, the specific mechanism of miR-205 is unclear. Here, we investigated the relationship between miR-205, thrombospondin 1 (THBS1) expression, and hypertrophic scars, and showed that miR-205 inhibits cell proliferation and migration and induces apoptosis. Double luciferase analysis, Western blot, and real-time polymerase chain reaction showed that miR-205 downregulates THBS1 expression and activity. Compared to the control group, miR-205 inhibited hypertrophic scar development. Our findings contribute to a better understanding of the miR-205-THBS1 pathway as a promising therapeutic target for reducing hypertrophic scars.