Aging
Navigate
Submit an Article
Research Paper|Volume 12, Issue 14|pp 14569—14581

High serum uric acid is associated with increased arterial stiffness in hypertension

Li-Na An1,2, Ning Rong3, Min Ning1, Liu-Liu Feng2, Zhen-Han Chen4, Wei-Qing Liu5, Xiao-Chun Ouyang6, Fan-Rong Diao7, Zhi-Gang Han8, Jiang Hong9
  • 1Department of Geriatrics, Shanghai First People’s Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China
  • 2Department of Cardiology, Shidong Hospital of Shanghai Yangpu, Shanghai 200433, China
  • 3Department of Neurology, School of Clinical Medicine, Dali University, YunNan 671000, China
  • 4Community Health Service Center, Shanghai 200435, China
  • 5Community Health Service Center, Shanghai 201914, China
  • 6Department of Neurology, No.908 Hospital of the People's Liberation Army Joint Logistics Support Force, JiangXi 330000, China
  • 7Department of Cardiology, Changhai Hospital, Naval Military Medical University, Shanghai 200433, China
  • 8Department of Radiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
  • 9Department of Emergency, Shanghai First People's Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China
* Co-first authors
Received: March 9, 2020Accepted: June 4, 2020Published: July 23, 2020
https://doi.org/10.18632/aging.103506

Copyright: © 2020 An et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Serum uric acid level has been found to be associated with cerebrovascular diseases. However, whether serum uric acid level is a risk factor for arterial stiffness in the hypertension population is unclear. This study was designed to determine the relationship between serum uric acid level and arterial stiffness in the hypertension population. A total of 10450 participants were evaluated for the risk of arterial stiffness. Brachial-ankle pulse wave velocity (baPWV) was assessed, and high baPWV was determined as the highest quartile of baPWV values in a sex-specific manner. We evaluated the association between serum uric acid level and baPWV through multivariate-adjusted linear and logistic regression analyses. There was a significant difference on high baPWV between patients with quartiles of serum uric acid level in females and males (p<0.01), respectively. The odds ratios (95% CI) of the highest baPWV quartile across the sex-specific serum uric acid level were 1.0, 1.71 (1.35, 2.17), 1.75 (1.38, 2.23), and 1.95 (1.51, 2.51) in female, and 1.0, 1.33 (1.09, 1.64), 1.36 (1.11, 1.67), and 1.67 (1.36, 2.04) in male after adjusting for potential confounders. In conclusion, serum uric acid level could be considered as an important risk factor for arterial stiffness in Chinese hypertension population.